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MYP_032794
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Basic Information
Alloferon [H1PHE(4-OMe)]
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGVSGHGQHGVHG
Physicochemical Analysis
0.00 Da
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002585 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antiviral
HSV-1 McIntyre strain
PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0012155 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
None
None
The 'X' at position 1 indicates 4-Chloro-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0015638 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
None
None
The 'X' at position 1 indicates Phenylglycine
Bio-Activity Profile
Antimicrobial Antiviral
Herpesvirus 1 McIntire (HHV-1MC):inhibition of virus replication in Vero cells
190 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0023947 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine.
Bio-Activity Profile
Antiviral Entry inhibition
Herpesvirus 1 McIntire (HHV-1MC) | Vero cells
220 μM
IC50
PaperNew alloferon analogues: synthesis and antiviral properties. | Kuczer M, Majewska A, Zahorska R. | Chem Biol Drug Des. 2013 Feb;81(2):302-9. | DOI:10.1111/cbdd.12020 | PMID:22883213 PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
RECORD: Rec_0074737 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
ambiguous/noncanonical residue annotation [Modified]
None
None
The 'X' at position 1 indicates 4-Methoxy-phenylalanine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
toxic against Vero cells up to 312 μM
312 μM
Cytotoxicity
PaperNew alloferon analogues: synthesis and antiviral properties. Chem Biol Drug Des. 2013 Feb;81(2):302-309. doi: 10.1111/cbdd.12020. PMID: 22883213. PMID22883213 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22883213/
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