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MYP_032596
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Basic Information
Pexiganan acetate
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
22 amino acids
C122H209N31O23
Standard
Sequence
GIGKFLKKAKKFGKAFVKILKK
Physicochemical Analysis
2478.16 Da
10.90
8.75
8.53
0.3978
-0.16
0.79
-0.06
-6.16
93.18
0.1364
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
908.60
-2.76
32.0
32.0
94.0
176.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188039 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium ATCC 51559 (vancomycin resistant)
4 μg/mL
MIC
PaperPubMed PMID: 10103181 PMID10103181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10103181/
RECORD: Rec_0193752 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pexiganan acetate [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory Wound healing
Streptococcus group C 5 strains
16-64 μg/mL
MIC
PaperPotential therapeutic applications of magainins and other antimicrobial agents of animal origin.
RECORD: Rec_0197948 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Magainin-like peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0201270 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pexiganan acetate [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory Wound healing
Also anaerobic bacteria: B. fragilis 6 strains
4-8 μg/mL
MIC
PaperPotential therapeutic applications of magainins and other antimicrobial agents of animal origin.
RECORD: Rec_0206448 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Pexiganan acetate [Synthetic]
Magainin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory Wound healing
C. sporogenes 2 strains
8-32 μg/mL
MIC
PaperPotential therapeutic applications of magainins and other antimicrobial agents of animal origin.
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