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MYP_032569
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Basic Information
HYL-8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
Standard
16 amino acids
C72H128N20O19S2
Standard
Sequence
GIMSSLMAKLAAHIAK
Physicochemical Analysis
1642.04 Da
10.00
1.85
1.59
0.1153
0.91
0.49
0.34
68.13
122.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
621.00
-4.72
22.0
24.0
57.0
113.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018442 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
A549
15.17±0.34 μM
IC50
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32463
RECORD: Rec_0026374 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116
19.81±0.2 μM
IC50
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32463
RECORD: Rec_0029709 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32463
RECORD: Rec_0051087 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HYL
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(8) and Ⓧ (12) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Cytotoxicity
NCM460
3.04±0.10 μg/mL
IC50
PaperStructural modification and antitumor activity of antimicrobial peptide HYL. Chinese Chemical Letters. 2020;31(5):1288-1292. DOI:10.1016/j.cclet.2019.10.013. Evidence URLhttps://doi.org/10.1016/j.cclet.2019.10.013
RECORD: Rec_0068227 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Hep-G2
17.09±0.26 μM
IC50
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP32463
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