Peptide Database

Peptide NameAlpha-toxin CsE5

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC304H460N80O99S8

DescriptionStandard

        KKDGYPVDSGNCKYECLKDDYCNDLCLERKADKGYCYWGKVSCYCYGLPDNSPTKTSGKCNPA
    

Molecular Weight7075.90 Da

Isoelectric Point (pI)7.65

Net Charge (pH 7.0)0.68

Net Charge (pH 7.4) 0.33

Charge Density (pH 7.0) 0.0108

GRAVY Index-0.97

Hydrophobic Moment 0.52

Boman Index-0.19

Instability Index25.46

Aliphatic Index 37.14

Aromaticity 0.1270

Extinction Coeff. Reduced 15930.00

Extinction Coeff. Oxidized 16430.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2915.28

LogP -32.69

H-bond Donors 107.0

H-bond Acceptors 108.0

Rotatable Bonds 229.0

Heavy Atoms 491.0

Ring Count 13.0

Amide Bonds 66.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0115791 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides sculpturatus [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-60; 16-36; 22-43; 26-45

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense