Peptide Database

Peptide NameSLAY-screened peptide P4721

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC103H147N27O29

DescriptionStandard

        PTDFLFDSPRNIYRHYVS
    

Molecular Weight2227.43 Da

Isoelectric Point (pI)7.17

Net Charge (pH 7.0)0.05

Net Charge (pH 7.4) -0.07

Charge Density (pH 7.0) 0.0026

GRAVY Index-0.71

Hydrophobic Moment 0.72

Boman Index-0.10

Instability Index100.02

Aliphatic Index 59.44

Aromaticity 0.2222

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 906.56

LogP -7.62

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 66.0

Heavy Atoms 159.0

Ring Count 7.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0231982 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/