Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length457 amino acids

Chemical FormulaC2249H3625N593O635S18

DescriptionStandard

        MSLCCLLILVAVIPMTSGTNPGVKVKLTEKGLEYGRQLGMVSIQQKLKSIKVPDISGKQKVSPIGKVRYSLSNMQIVNVGLPKSAVDLVPGTGVKLSIGNAFISLHGNWRVKYLRVIKDRGSFDLNVKGLTISTSIAVKSDETGRPAVSSVNCAATVGSVSIKFHGGASWLYNLFKKFVNKALRNALQKQICPLVANAVSDLNPHLKTLNVLAKVDKYAEIEYSMVSSPTVSKSSIDLSLKGEFYNIGKHREPPFSPAAFYLPPQVNNMLYIGMSAYTANSAGFAYNTAGALSLYITDDMIPQSSPIRLTTRTFGAFIPQIAKRFPGLMMKLLLKTEKAPAVTFEPNNVTIQASAAVTAYAIQPNATLSPLFVLNLETSVSAKVFVSGMRLAGAVTLNKMDLTLRTSYVGDFQVRSLDSILQLVLKVVVIPKVNDPHQHFMDSSLHQVWCKSVQYFQ
    

Molecular Weight49708.60 Da

Isoelectric Point (pI)9.77

Net Charge (pH 7.0)24.06

Net Charge (pH 7.4) 23.31

Charge Density (pH 7.0) 0.0526

GRAVY Index0.15

Hydrophobic Moment 0.81

Boman Index0.13

Instability Index31.33

Aliphatic Index 101.71

Aromaticity 0.0788

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103931 VERIFIED: NO

Provenance & Taxonomy

OrganismScophthalmus maximus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence