Peptide Database

Peptide NameT1967(FIV envelope protein (728-760))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC174H265N45O57S

DescriptionStandard

        GNITLGEWYNQTKDLQQKFYEIIMDIEQNNVQG
    

Molecular Weight3931.30 Da

Isoelectric Point (pI)4.18

Net Charge (pH 7.0)-3.23

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.0980

GRAVY Index-0.86

Hydrophobic Moment 0.59

Boman Index-0.04

Instability Index59.61

Aliphatic Index 79.70

Aromaticity 0.1212

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1717.58

LogP -16.25

H-bond Donors 55.0

H-bond Acceptors 55.0

Rotatable Bonds 135.0

Heavy Atoms 277.0

Ring Count 5.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0311339 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 | CEM4/IIIb cells; MOLT4 cells

Activity2.518 μM

MethodEC90

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

RECORD: Rec_0365838 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetFeline immunodeficiency virus (FIV):inhibition of cell-cell fusion between FIV/CrFK cells and HeLa cells

Activity2.454 μM

MethodEC50

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