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MYP_032371
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Basic Information
P148(derived from HCV polyprotein)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
13 amino acids
C78H125N17O15
Standard
Sequence
KKKKVVAAFYVLF
Physicochemical Analysis
1540.93 Da
10.18
3.76
3.54
0.2889
0.67
0.38
0.17
27.78
112.31
0.2308
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
536.83
0.22
19.0
19.0
52.0
110.0
3.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus(HCV):inhibition of activation of NS3-6K protease
8 %
Inhibition
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0116769 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptide inhibitors of hepatitis C virus NS3 protease. Antivir Chem Chemother. 2003 Sep;14(5):225-33. doi: 10.1177/095632020301400501. PMID: 14694985. PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0212969 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibitor
Hepatitis C virus (NS3 protease); BL21(DE3)
8 %
Fluorescent probe
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Nunez S, Gonzalez-Navarro CJ, Garcia-Delgado M, Vizmanos JL, Lasarte JJ, Borras-Cuesta F. | Antivir Chem Chemother. 2003 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/
RECORD: Rec_0239786 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 46.2%, C 53.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0259852 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Replication inhibition
Hepatitis C virus (HCV)
3 μM
% inhibition
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperPeptide inhibitors of hepatitis C virus NS3 protease. | Portal-Núñez S, González-Navarro CJ, García-Delgado M, Vizmanos JL, Lasarte JJ, Borrás-Cuesta F. | Antivir Chem Chemother. 2003 Sep;14(5):225-33. | DOI:10.1177/095632020301400501 | PMID:14694985 PMID14694985 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14694985/