Peptide Database

Peptide NamegmuD signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC142H200N38O43S2

DescriptionStandard

        MAHTEQYRFPKDFWWGSSASATQMEGAA
    

Molecular Weight3191.47 Da

Isoelectric Point (pI)5.43

Net Charge (pH 7.0)-1.41

Net Charge (pH 7.4) -1.68

Charge Density (pH 7.0) -0.0503

GRAVY Index-0.71

Hydrophobic Moment 0.48

Boman Index0.02

Instability Index14.99

Aliphatic Index 17.86

Aromaticity 0.1786

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1307.87

LogP -13.42

H-bond Donors 46.0

H-bond Acceptors 45.0

Rotatable Bonds 99.0

Heavy Atoms 225.0

Ring Count 9.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221904 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis subsp. subtilis str. 168 [Bacterium]

FamilyTat signal peptide

Tax ID224308

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity9001.8 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/