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MYP_032312
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Basic Information
AP-57
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Standard
57 amino acids
C286H473N97O70S4
Standard
Sequence
KRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV
Physicochemical Analysis
6518.68 Da
11.28
10.98
10.56
0.1927
-0.75
0.50
-0.26
71.31
71.75
0.0351
11000.00
11250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2670.54
-26.59
98.0
88.0
206.0
457.0
15.0
59.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0202725 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-positive
Staphylococcus aureus
PMID25585381 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25585381/
RECORD: Rec_0225292 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
proteomic study of secreted proteins. Sequence analysis: APD analysis reveals that this sequence is similar (32.76%) to VicBac P=R: 14%, L: 11%. GRAVY: -0.75; Mol Wt: 6518.767; mol formula: C286H477N95O70S4; mol ex coeff: 11350. Poor similarity to known AMPs. Chemical modification: predicted two disulfide bonds: C1-C4 and C2-C3
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
ATCC 19115
>200 μg/mL
MEC
PaperAP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
RECORD: Rec_0232280 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
proteomic study of secreted proteins. Sequence analysis: APD analysis reveals that this sequence is similar (32.76%) to VicBac P=R: 14%, L: 11%. GRAVY: -0.75; Mol Wt: 6518.767; mol formula: C286H477N95O70S4; mol ex coeff: 11350. Poor similarity to known AMPs. Chemical modification: predicted two disulfide bonds: C1-C4 and C2-C3
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
S. typhi RE88
91.69 μg/mL
MEC
PaperAP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
RECORD: Rec_0255453 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
proteomic study of secreted proteins. Sequence analysis: APD analysis reveals that this sequence is similar (32.76%) to VicBac P=R: 14%, L: 11%. GRAVY: -0.75; Mol Wt: 6518.767; mol formula: C286H477N95O70S4; mol ex coeff: 11350. Poor similarity to known AMPs. Chemical modification: predicted two disulfide bonds: C1-C4 and C2-C3
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Adenovirus Ad5
>200 μg/mL
MEC
PaperAP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
RECORD: Rec_0285001 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
proteomic study of secreted proteins. Sequence analysis: APD analysis reveals that this sequence is similar (32.76%) to VicBac P=R: 14%, L: 11%. GRAVY: -0.75; Mol Wt: 6518.767; mol formula: C286H477N95O70S4; mol ex coeff: 11350. Poor similarity to known AMPs. Chemical modification: predicted two disulfide bonds: C1-C4 and C2-C3
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
ATCC 2601
>200 μg/mL
MEC
PaperAP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
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