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MYP_032276
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Basic Information
Pep19-4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C141H191N37O22
Standard
Sequence
GKKYRRFRWKFKFGKWFWFG
Physicochemical Analysis
2756.26 Da
11.76
7.75
7.54
0.3877
-1.21
0.51
-0.25
42.32
0.00
0.4500
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
999.62
-0.73
39.0
30.0
89.0
200.0
12.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0339801 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
TZM-bl
8 μM
IC50
PaperA new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses. PMID22457281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22457281/
RECORD: Rec_0408123 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1 | Vero cells
1.8 μg/mL
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses. | Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U. | J Infect Dis. 2012 Jun;205(11):1654-64. | DOI:10.1093/infdis/jis273 | PMID:22457281 PMID22457281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22457281/
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