Peptide Database

Peptide NameNeurexophilin-4

Function Ontology

Annotation / Sequence feature ▸ Secretory pathway ▸ Secreted peptide

Annotation / Sequence feature ▸ Secretory pathway ▸ Secreted protein

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC416H611N109O114S6

DescriptionStandard

        NCHVEYEKTNRARKHRPCLYDPSQVCFTEHTQSQAAWLCAKPYKVICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG
    

Molecular Weight9155.35 Da

Isoelectric Point (pI)8.27

Net Charge (pH 7.0)2.05

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.0266

GRAVY Index-0.48

Hydrophobic Moment 0.52

Boman Index-0.04

Instability Index35.04

Aliphatic Index 58.18

Aromaticity 0.1688

Extinction Coeff. Reduced 14440.00

Extinction Coeff. Oxidized 14815.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3592.34

LogP -30.49

H-bond Donors 128.0

H-bond Acceptors 126.0

Rotatable Bonds 289.0

Heavy Atoms 645.0

Ring Count 23.0

Amide Bonds 84.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0007811 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyNeurexophilin

Tax ID9544

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation

Targetalpha-neurexins and possibly other receptors

Half-LifeMammalian: 1.4 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0064807 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca mulatta [Animal]

FamilyNeurexophilin

Tax ID9544

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Secreted peptide Secreted protein

RECORD: Rec_0101305 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/