Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 14.2

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC133H211N41O42S6

DescriptionStandard

        TPFAIKCATDADCSRKCPGNPPCRNGFCACT
    

Molecular Weight3248.74 Da

Isoelectric Point (pI)8.30

Net Charge (pH 7.0)1.34

Net Charge (pH 7.4) 1.06

Charge Density (pH 7.0) 0.0432

GRAVY Index-0.28

Hydrophobic Moment 0.37

Boman Index-0.08

Instability Index46.77

Aliphatic Index 25.48

Aromaticity 0.0645

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1318.70

LogP -18.96

H-bond Donors 50.0

H-bond Acceptors 50.0

Rotatable Bonds 97.0

Heavy Atoms 222.0

Ring Count 6.0

Amide Bonds 32.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0199256 VERIFIED: YES

Provenance & Taxonomy

OrganismMesobuthus martensii [Animal]

FamilyPotassium channel inhibitor family

Tax ID34649; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-23; 13-28; 17-30

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor family Host defense

RECORD: Rec_0370152 VERIFIED: NO