Peptide Database

Peptide NameBrevinin-2-OR5 (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC144H246N38O49S2

DescriptionStandard

        SFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC
    

Molecular Weight3357.85 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.44

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0134

GRAVY Index0.40

Hydrophobic Moment 0.41

Boman Index0.15

Instability Index23.88

Aliphatic Index 103.64

Aromaticity 0.0303

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1415.43

LogP -18.70

H-bond Donors 52.0

H-bond Acceptors 52.0

Rotatable Bonds 115.0

Heavy Atoms 233.0

Ring Count 1.0

Amide Bonds 34.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0222029 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide27-33

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetCandida albicans

Activity6.6 μg/mL

MethodMIC

RECORD: Rec_0224731 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide27-33

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity3.93 μM

MethodMIC

RECORD: Rec_0266293 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans ATCC 2002

Activity6.6 μg/mL

MethodMIC

RECORD: Rec_0316402 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli ATCC 25922

Activity13.2 μg/mL

MethodMIC

RECORD: Rec_0323316 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide27-33

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

FIRST PREV 1 2 3 4 NEXT LAST

Showing 5 records on this page Ã‚Â· Page 3 of 4