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MYP_032069
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Basic Information
Peptide3
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
23 amino acids
C125H171N31O42
Standard
Sequence
DKFNHEAEDLFYQSSLASWNYNT
Physicochemical Analysis
2779.88 Da
4.31
-3.15
-3.41
-0.1369
-1.08
0.53
-0.08
57.57
42.61
0.2174
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1216.95
-12.67
41.0
40.0
88.0
198.0
7.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015802 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0113792 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)
6±4 μM
IC50
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0373758 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 | HEK293T/ACE2 cells
0.006±0.004 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein | Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. | J Med Chem. 2022 Feb 24;65(4):2836-2847. | DOI:10.1021/acs.jmedchem.1c00477 | PMID:34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/