Peptide Database

Peptide NameBradykinin-potentiating peptide 14a

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC81H116N22O19

DescriptionStandard

        QWAQWPRPTPQIPP
    

Molecular Weight1701.92 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0543

GRAVY Index-1.37

Hydrophobic Moment 0.51

Boman Index-0.07

Instability Index32.38

Aliphatic Index 35.00

Aromaticity 0.1429

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 640.65

LogP -3.81

H-bond Donors 19.0

H-bond Acceptors 20.0

Rotatable Bonds 42.0

Heavy Atoms 122.0

Ring Count 9.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019627 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 14a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods4:Pyrrolidone carboxylic acid

Bio-Activity Profile

Function

Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Targetangiotensin-converting enzyme

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0284661 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic

RECORD: Rec_0345749 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararaca [Animal]

FamilyBradykinin-potentiating peptide 14a

Tax ID8724

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods4:Pyrrolidone carboxylic acid

Bio-Activity Profile

Function

Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour