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MYP_032006
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Basic Information
Peptide 120
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
7 amino acids
C67H76N18O8
Standard
Sequence
RWWWRWW
Physicochemical Analysis
1261.44 Da
12.00
1.76
1.56
0.2514
-1.93
0.90
-0.14
172.23
0.00
0.7143
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
440.67
3.45
19.0
10.0
31.0
93.0
10.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061366 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
horse RBCs
Hemolysis
PMID34021253 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34021253/
RECORD: Rec_0095489 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Methicillin-resistant Staphylococcus aureus (MRSA)
100 μg/mL
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP28997
RECORD: Rec_0185492 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
69.01067253 μM
MIC
PMID34021253 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34021253/
RECORD: Rec_0327368 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
19±4 μg/mL
MIC
PaperZhixia Chen, Xiuli Yu, Aiying Zhang, Fangfang Wang, Yankun Xing. De Novo Hydrocarbon-Stapling Design of Single-Turn α-Helical Antimicrobial Peptides. Int J Pept Res Ther. 2019 Nov 14; 26(4):1711-1719. doi: 10.1007/s10989-019-09964-7. Evidence URLhttps://doi.org/10.1007/s10989-019-09964-7
RECORD: Rec_0327409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC25923
83±18 μg/mL
MIC
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?id=DRAMP28997
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