Peptide Database

Peptide NameGrammistin PpIIb (Group II grammistin; fish, chordates, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC76H119N15O15

DescriptionStandard

        FIGGIISFIKKLF
    

Molecular Weight1482.85 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1352

GRAVY Index1.60

Hydrophobic Moment 0.58

Boman Index0.61

Instability Index-0.87

Aliphatic Index 150.00

Aromaticity 0.2308

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 484.79

LogP 0.69

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 50.0

Heavy Atoms 106.0

Ring Count 3.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040738 VERIFIED: YES

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

Targetputrefaciens IAM 1509

Activity6.25 μg/mL

MethodMIC

RECORD: Rec_0053758 VERIFIED: NO

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]; Grammistes sexlineatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Toxin

RECORD: Rec_0056410 VERIFIED: NO

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

FamilyGrammistin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence

RECORD: Rec_0066091 VERIFIED: YES

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis IAM 1026

Activity6.25 μg/mL

MethodMIC

RECORD: Rec_0072711 VERIFIED: YES

Provenance & Taxonomy

OrganismPogonoperca punctata [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetVibrio anguillarum NCIBM 829

Activity12.5 μg/mL

MethodMIC

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