Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length168 amino acids

Chemical FormulaC852H1311N197O253S11

DescriptionStandard

        MRHIYKMTGIVFPAGNYSDSSYVAASFTIPDQSDSMLYLALSEYFFQMSPFAYYTAGAFNMIVAEEVEKCSAPYPLMLKLMSTEIPIISLQRDSFTVKTQGSVEVLAILPDSTTRFLFILKTADNTSIPLNIFDQKLMGSLCLNSDSSGFISLQFSSYPQPTPMLDLL
    

Molecular Weight18714.41 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-6.42

Net Charge (pH 7.4) -6.75

Charge Density (pH 7.0) -0.0382

GRAVY Index0.24

Hydrophobic Moment 0.53

Boman Index0.20

Instability Index51.44

Aliphatic Index 90.60

Aromaticity 0.1250

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 13535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7123.07

LogP -68.13

H-bond Donors 245.0

H-bond Acceptors 259.0

Rotatable Bonds 602.0

Heavy Atoms 1313.0

Ring Count 33.0

Amide Bonds 179.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0367910 VERIFIED: NO

Provenance & Taxonomy

OrganismLonchura striata domestica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence