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MYP_031920
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Basic Information
cPcAMP1/26
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C164H238N32O31
Standard
Sequence
PPHKKKLAVYPVFLFYLFLSWFSLIV
Physicochemical Analysis
3153.84 Da
9.84
3.04
2.93
0.1169
0.93
0.32
0.45
41.39
127.31
0.2692
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
962.70
3.15
34.0
35.0
94.0
227.0
12.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012247 VERIFIED: YES
Provenance & Taxonomy
Paramecium caudatum [Protist]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Aeromonas hydrophila ATCC 35654 (killed 77% at 25 ug/ml)
PaperIdentification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum
RECORD: Rec_0012756 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Active against A. hydrophila
PMID26883426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26883426/
RECORD: Rec_0050464 VERIFIED: YES
Provenance & Taxonomy
Paramecium caudatum [Protist]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
cPcAMP1/26 showed little hemolytic activity towards human erythrocytes at 100 μg/ml
PMID26883426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26883426/
RECORD: Rec_0089302 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0099217 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Low Hemolytic activity against Human RBC
Hemolysis
PMID26883426 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26883426/
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