Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length516 amino acids

Chemical FormulaC2541H4041N697O710S19

DescriptionStandard

        MAGAAGPMAGAAVWGTAPTGHASRSQPVWLCFLLLLPTCVSATTTSPGIKVWLTQRTLEFGRRFGLELLQSMLQKEHELNLTGSYNTLLGTLTYAVPRIRIHELQMNESTLDFAEDVGLRLTVQRARVQLSADWAAQLGAVQDSGSVQLGMQDVAMAAVLGVSEDGGGHPTVWSAGCDTHGTDLHMEFHRGYSWLYNLLAPLLQRTLRQQLNKQLCLMLQRGIDRLDTALKHMKVSTQLDTIAAIDHSLLAPPAFTEEYGDIALKGEIFRVGTYQQRPPALPVALPVALPMALPVALPTALPTTPPMAHEPTLLLAVTEFVANSAAFTYFSAGALRRIISSDMVPRRFPLQLSTKSMGIFSPQLQELYPDQPMELHLWARQQPLLSCHPDALHGTLLGSAEAFVVLPNATRAPAFLLHIDANVTGKPTITRNRLGGTVRLTGLHITQVASNVGPVEVKRLETLLKFSLWLFGVPRANKWLQAGIPLPLPHGLSLLRPRLSLHQGFVLIATDLQYEP
    

Molecular Weight56323.75 Da

Isoelectric Point (pI)8.26

Net Charge (pH 7.0)2.99

Net Charge (pH 7.4) 1.76

Charge Density (pH 7.0) 0.0058

GRAVY Index0.11

Hydrophobic Moment 0.76

Boman Index0.14

Instability Index44.26

Aliphatic Index 102.89

Aromaticity 0.0678

Extinction Coeff. Reduced 62910.00

Extinction Coeff. Oxidized 63160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042186 VERIFIED: NO

Provenance & Taxonomy

OrganismJunco hyemalis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence