Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length504 amino acids

Chemical FormulaC2510H3928N648O733S15

DescriptionStandard

        MGPVLCGCLLLWTLHVPATQAAHPGIKARVTQRALDYGVQAGMEIMEQMVKQKHIPDLKGSETLEFLKIDYVNYNFSNIKIHTFSFPNTSLAFVPGVGIRALTNHGTANISADWEVRAPLFRDAGGADLFLSGVYFTGVIIPTQDAFSHPALKLQDCYAQVSHAQVSFTGDLSALYNTFAEPMEKPILRNLNAVLCPLISDEAAGLNTNLSSLEVLTKIDNFTLLDYSLISPPEITEHYLDLNLKGAFYPLEDLTDPRFSPEPFDLPEHSDSMLYIGISEYLFRSASLAHFAAGAFSVTLSTKEISNHLIQNSQGIGNVFSRLADLYILFQPLVLRIMATEPPVVRLQPGNFSLEIPASAILLTQPQNSSELEPIVSMDFVASTSVGLAILGQRLICSLSLNRFRLSVPESNRSDIKVLRFENILSSILHFGVLPLANTKLQQGFPLPQPYNISLVNSDIEVLEGFVLISTDLKYEMSSRQQPSFHGLGDLNLIRGQGMGQPAP
    

Molecular Weight55390.91 Da

Isoelectric Point (pI)5.23

Net Charge (pH 7.0)-15.35

Net Charge (pH 7.4) -16.39

Charge Density (pH 7.0) -0.0305

GRAVY Index0.12

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index41.00

Aliphatic Index 104.31

Aromaticity 0.0873

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0204143 VERIFIED: NO

Provenance & Taxonomy

OrganismFukomys damarensis [Animal]

FamilyBPI/LBP

Tax ID885580

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria