Peptide Database

Peptide NameEndothelin 3

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC121H172N26O34S4

DescriptionStandard

        CTCYTYKDKECVYYCHLDIIW
    

Molecular Weight2663.07 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-1.19

Net Charge (pH 7.4) -1.52

Charge Density (pH 7.0) -0.0568

GRAVY Index-0.10

Hydrophobic Moment 0.26

Boman Index0.09

Instability Index52.10

Aliphatic Index 69.52

Aromaticity 0.2381

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11710.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 975.11

LogP -4.08

H-bond Donors 39.0

H-bond Acceptors 38.0

Rotatable Bonds 81.0

Heavy Atoms 185.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0124911 VERIFIED: YES

Provenance & Taxonomy

OrganismRana ridibunda [Animal]

Structure & Mods

Configdisulfide-constrained peptide with linear backbone [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Neuropeptide Endothelin Stimulates corticosteroid secretion

TargetRana ridibunda interrenal gland slices (corticosterone secretion)

Activity8.13±0.16 -log M

MethodEC50 (perifused interrenal gland steroid secretion assay)

RECORD: Rec_0433312 VERIFIED: YES