Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length385 amino acids

Chemical FormulaC1935H3029N497O566S14

DescriptionStandard

        MRRESLLVLGICWLLPSSEGVNPGFAGRITKKGLDYACLEGVATLQKDLPAITLPEFSGSYRVKIIGNVQYTFYSLNIRRFELFHSTIEPMPGQGLRVSISNALAEMTGRWKLKKRWLKDDGSFELKVDGISISVGLKLGSDSTGRPTVTTLDCNTHISNVDIDISGKWEWLYNLFESKVESAFKRAMESKICEIVRLSINSKLQSHLQSLPVTANIDHTSSIDYSLVGPPVVTSQCVDLDLKGEFFSTTHRSPAPFPPPPLSFPVDPDHMVQFGISTYFFNTAGDVYYKSGSLTFWIVDEMVPQEVKIRLNTSSFQPFIPQLKKLYPNMAMKLKVSPSSVPSLSISPETISLTPSVDIQAFAILPNSSLAPLYNRSDQPSFCQS
    

Molecular Weight42759.65 Da

Isoelectric Point (pI)7.60

Net Charge (pH 7.0)1.00

Net Charge (pH 7.4) 0.30

Charge Density (pH 7.0) 0.0026

GRAVY Index-0.08

Hydrophobic Moment 0.66

Boman Index0.09

Instability Index52.22

Aliphatic Index 90.34

Aromaticity 0.0961

Extinction Coeff. Reduced 49390.00

Extinction Coeff. Oxidized 49765.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0200972 VERIFIED: NO

Provenance & Taxonomy

OrganismNaja naja [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence