‹ ›
MYP_031583
← PREVIOUS NEXT → BACK
Basic Information
Entry 1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
8 amino acids
C31H59N13O10S
Standard
Sequence
GKRKSGCA
Physicochemical Analysis
805.95 Da
10.06
2.75
2.53
0.3435
-1.20
0.29
-0.48
38.89
12.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
401.19
-6.48
16.0
14.0
29.0
55.0
0.0
7.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0091612 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0124989 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
The N-terminal and C-terminal cyclized by a amide bond.
Bio-Activity Profile
Antiviral Anti-DENV Replication inhibition
Dengue virus 2(DENV2)
114.2 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity. | Takagi Y, Matsui K, Nobori H, Maeda H, Sato A, Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K, Numata Y, Yoshida Y. | Bioorg Med Chem Lett. 2017 Aug 1;27(15):3586-3590. | DOI:10.1016/j.bmcl.2017.05.027 | PMID:28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0260456 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 2(DENV2):inhibition of the activity of NS2B-NS3 protease
114.2 μM
IC50
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/