Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 2.11

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC187H315N51O50S7

DescriptionStandard

        TIINVKCTSPKQCLLPCKEIYGIHAGAKCMNGKCKCYKI
    

Molecular Weight4302.27 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)5.42

Net Charge (pH 7.4) 5.08

Charge Density (pH 7.0) 0.1390

GRAVY Index0.03

Hydrophobic Moment 0.38

Boman Index0.04

Instability Index42.43

Aliphatic Index 82.56

Aromaticity 0.0513

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1630.08

LogP -14.52

H-bond Donors 61.0

H-bond Acceptors 64.0

Rotatable Bonds 146.0

Heavy Atoms 295.0

Ring Count 5.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298007 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides elegans [Animal]

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide7-29; 13-34; 17-36

Bio-Activity Profile

Function

Kv1.3 potassium channel blocker Ion-channel inhibitor Toxin

Targethuman T-lymphocyte Kv1.3 potassium channel

Activity0.98 nM

MethodKd (whole-cell patch-clamp)