Peptide Database

Peptide NameACE inhibitory peptide

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC47H90N16O10

DescriptionStandard

        KLLLRRLQ
    

Molecular Weight1039.32 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.3449

GRAVY Index-0.15

Hydrophobic Moment 0.67

Boman Index-0.40

Instability Index134.56

Aliphatic Index 195.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 459.93

LogP -2.10

H-bond Donors 17.0

H-bond Acceptors 13.0

Rotatable Bonds 38.0

Heavy Atoms 73.0

Ring Count 0.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010445 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

FamilyBioactive peptides

Tax ID3885

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme

Activity0.093 μM

MethodIC50

RECORD: Rec_0062951 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

Tax ID3885.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antihypertensive ACE inhibitory

TargetAngiotensin-converting enzyme (ACE)

PaperMojica L., Chen K., de Mejia E.G.. Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin-Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase-IV. Journal of Food Science, 80, 188-198, DOI: 10.1111/1750-3841.12726. PMID25495131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25495131/

RECORD: Rec_0285543 VERIFIED: YES

Provenance & Taxonomy

OrganismPhaseolus vulgaris [Plant]

Tax ID3885.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antidiabetic DPP-IV inhibitory

TargetDipeptidyl peptidase IV

PaperMojica L., Chen K., de Mejia E.G.. Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin-Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase-IV. Journal of Food Science, 80, 188-198, DOI: 10.1111/1750-3841.12726. PMID25495131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25495131/