Peptide Database

Peptide NameHPV-31 L1 Ctb

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HPV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC60H114N20O17

DescriptionStandard

        TTTPAKRKKTKK
    

Molecular Weight1387.67 Da

Isoelectric Point (pI)11.39

Net Charge (pH 7.0)5.39

Net Charge (pH 7.4) 5.20

Charge Density (pH 7.0) 0.4494

GRAVY Index-2.22

Hydrophobic Moment 0.21

Boman Index-0.79

Instability Index52.38

Aliphatic Index 8.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 647.55

LogP -8.31

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 50.0

Heavy Atoms 97.0

Ring Count 1.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0333397 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0424591 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HPV Entry inhibition

TargetHuman papillomavirus(HPV) | particle cell

Activity7.206 μM

Method% inhibition

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperPositively charged synthetic peptides from structural proteins of papillomaviruses abrogate human papillomavirus infectivity. | Bousarghin L, Touzé A, Yvonnet B, Coursaget P. | J Med Virol. 2004 Jul;73(3):474-80. | DOI:10.1002/jmv.20114 | PMID:15170645 PMID15170645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15170645/

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