Peptide Database

Peptide NameDybowskin-4 (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC79H134N18O16S2

DescriptionStandard

        VWPLGLVICKALKIC
    

Molecular Weight1656.15 Da

Isoelectric Point (pI)8.90

Net Charge (pH 7.0)1.71

Net Charge (pH 7.4) 1.47

Charge Density (pH 7.0) 0.1141

GRAVY Index1.66

Hydrophobic Moment 0.45

Boman Index0.51

Instability Index-1.99

Aliphatic Index 175.33

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 529.76

LogP 0.73

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 52.0

Heavy Atoms 115.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386454 VERIFIED: YES

Provenance & Taxonomy

OrganismRana dybowskii [Animal]

FamilyDybowskin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide9-15

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity9.1 μM

MethodMIC

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