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MYP_031486
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Basic Information
Dybowskin-4 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
15 amino acids
C79H134N18O16S2
Standard
Sequence
VWPLGLVICKALKIC
Physicochemical Analysis
1656.15 Da
8.90
1.71
1.47
0.1141
1.66
0.45
0.51
-1.99
175.33
0.0667
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
529.76
0.73
20.0
20.0
52.0
115.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294754 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
hRBC
100 μg/mL
Hemolysis
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0295094 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
9-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis ATCC6633
6.25 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0297680 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Dybowskin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
9-15
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
60.42 μM
HC50
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii
RECORD: Rec_0299886 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
100 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0315120 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
6.25 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
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