Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2314H3705N581O671S20

DescriptionStandard

        MSSCCWLALLALVPLAMATNPGVKVKLTENGIEYGKKIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPNSALALVPDTGISLSITNAVISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSDYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPMPFSLPPQVNNMLYIGISAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPGMMIKLLVKTVKEPTIFFEPNNGTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGPFQVGSLDNIFLMVLKVAVIPKVNARLEKGFPLPAIGKMSLVNTQLQVLKDYMLIGTDVLFTG
    

Molecular Weight51041.96 Da

Isoelectric Point (pI)8.98

Net Charge (pH 7.0)6.83

Net Charge (pH 7.4) 6.24

Charge Density (pH 7.0) 0.0144

GRAVY Index0.23

Hydrophobic Moment 0.76

Boman Index0.19

Instability Index28.60

Aliphatic Index 102.41

Aromaticity 0.0803

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225183 VERIFIED: NO

Provenance & Taxonomy

OrganismSalmo salar [Animal]

FamilyBPI/LBP

Tax ID8030

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria