Peptide Database

Peptide Namep2(gag) peptide[ΔM4]

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Enzyme modulation ▸ Enzyme inhibition ▸ Maturation inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC54H93N15O22S

DescriptionStandard

        AEASQVTNTATIM
    

Molecular Weight1336.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.20

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0924

GRAVY Index0.20

Hydrophobic Moment 0.26

Boman Index0.17

Instability Index-6.38

Aliphatic Index 75.38

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 616.92

LogP -9.13

H-bond Donors 21.0

H-bond Acceptors 22.0

Rotatable Bonds 43.0

Heavy Atoms 92.0

Ring Count 0.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0387570 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV

TargetHIV | CEM/LAV-1 cells

Activity126 μM

MethodIC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. | Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S. | J Biochem. 2004 Mar;135(3):447-53. | DOI:10.1093/jb/mvh052 | PMID:15113844 PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/

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