MYP_031238
Ranacyclin-T
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Antimicrobial
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Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-negative
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
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Antifungal
Toxicity / Safety
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Blood cell toxicity
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Hemolysis
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Hemolytic
Toxicity / Safety
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Cytotoxicity
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Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Venom / Toxin
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General toxin
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Toxic
Standard
17 amino acids
C85H134N24O21S2
Standard
GALRGCWTKSYPPKPCK
1892.25 Da
9.70
3.74
3.50
0.2198
-0.88
0.26
-0.15
25.56
28.82
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
718.99
-6.44
27.0
27.0
56.0
132.0
6.0
16.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0285346
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
Hemolytic
human erythrocytes
RECORD: Rec_0293056
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μM
Hemolysis
RECORD: Rec_0296672
VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond. It differs from ranacyclin E (next entry) only at the N-terminus. Active against Gram- E. coli D21 (MIC 30 uM), Y. pseudotuberculosis YP III (MIC 5 uM), Ps. syringae pv tabaci (MIC 16 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 10 uM), M. luteus (MIC 8 uM), fungi C. albicansc ATCC 10231 (MIC 22 uM), C. tropicalis (MIC 14 uM), C. guiller-mondii (MIC 1 uM), P. nicotianae spores (MIC 16 uM). 20% hemolysis at 100 uM. Updated 5/2020
Bio-Activity Profile
Antimicrobial
Antifungal
C. tropicalis
14 μM
MIC
RECORD: Rec_0301183
VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond. It differs from ranacyclin E (next entry) only at the N-terminus. Active against Gram- E. coli D21 (MIC 30 uM), Y. pseudotuberculosis YP III (MIC 5 uM), Ps. syringae pv tabaci (MIC 16 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 10 uM), M. luteus (MIC 8 uM), fungi C. albicansc ATCC 10231 (MIC 22 uM), C. tropicalis (MIC 14 uM), C. guiller-mondii (MIC 1 uM), P. nicotianae spores (MIC 16 uM). 20% hemolysis at 100 uM. Updated 5/2020
Bio-Activity Profile
Antimicrobial
Antifungal
Y. pseudotuberculosis YP III
5 μM
MIC
RECORD: Rec_0306755
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
Micrococcus luteus
8 μM
MIC
Showing 5 records on this page · Page 6 of 9