MYP_031238
Ranacyclin-T
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
▸
Cytotoxic
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-negative
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
▸
Antifungal
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Toxic
Standard
17 amino acids
C85H134N24O21S2
Standard
GALRGCWTKSYPPKPCK
1892.25 Da
9.70
3.74
3.50
0.2198
-0.88
0.26
-0.15
25.56
28.82
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
718.99
-6.44
27.0
27.0
56.0
132.0
6.0
16.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0232081
VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond. It differs from ranacyclin E (next entry) only at the N-terminus. Active against Gram- E. coli D21 (MIC 30 uM), Y. pseudotuberculosis YP III (MIC 5 uM), Ps. syringae pv tabaci (MIC 16 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 10 uM), M. luteus (MIC 8 uM), fungi C. albicansc ATCC 10231 (MIC 22 uM), C. tropicalis (MIC 14 uM), C. guiller-mondii (MIC 1 uM), P. nicotianae spores (MIC 16 uM). 20% hemolysis at 100 uM. Updated 5/2020
Bio-Activity Profile
Antimicrobial
Antifungal
S. lentus
10 μM
MIC
RECORD: Rec_0257791
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anti-Gram-positive
Anti-Gram-negative
P.syringae pv tabaci
RECORD: Rec_0258644
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anti-Gram-positive
Anti-Gram-negative
Candida albicans ATCC 10231
RECORD: Rec_0261202
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibacterial
Antifungal
Anti-Gram-positive
Anti-Gram-negative
C.guillermondii
RECORD: Rec_0262925
VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial
Antibacterial
Anti-Gram-positive
Anti-Gram-negative
Antifungal
Yersinia pseudotuberculosis YP III
5 μM
MIC
Showing 5 records on this page · Page 5 of 9