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MYP_031238
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Basic Information
Ranacyclin-T
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C85H134N24O21S2
Standard
Sequence
GALRGCWTKSYPPKPCK
Physicochemical Analysis
1892.25 Da
9.70
3.74
3.50
0.2198
-0.88
0.26
-0.15
25.56
28.82
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
718.99
-6.44
27.0
27.0
56.0
132.0
6.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167359 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
guillermondii
1 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0173552 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0183389 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond. It differs from ranacyclin E (next entry) only at the N-terminus. Active against Gram- E. coli D21 (MIC 30 uM), Y. pseudotuberculosis YP III (MIC 5 uM), Ps. syringae pv tabaci (MIC 16 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 10 uM), M. luteus (MIC 8 uM), fungi C. albicansc ATCC 10231 (MIC 22 uM), C. tropicalis (MIC 14 uM), C. guiller-mondii (MIC 1 uM), P. nicotianae spores (MIC 16 uM). 20% hemolysis at 100 uM. Updated 5/2020
Bio-Activity Profile
Antimicrobial Antifungal
C. guiller-mondii
1 μM
MIC
PaperRanacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity.
RECORD: Rec_0193706 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium Bm11
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0214104 VERIFIED: NO
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus megaterium, Staphylococcus lentus, Mycobacterium luteus, Yersinia pseudotuberculosis, Pseudomonas syringae, Candida tropicalis etc
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