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MYP_031238
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Basic Information
Ranacyclin-T
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C85H134N24O21S2
Standard
Sequence
GALRGCWTKSYPPKPCK
Physicochemical Analysis
1892.25 Da
9.70
3.74
3.50
0.2198
-0.88
0.26
-0.15
25.56
28.82
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
718.99
-6.44
27.0
27.0
56.0
132.0
6.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0118604 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli D22
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0128006 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Y.pseudotuberculosis YP III
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0151643 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0159154 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Phytophthora nicotianae spores
16 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0160839 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Head-to-tail cyclic peptide of the ranacyclin scaffold [Cyclic]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperM.L. Mangoni et al. / Biochemistry 42 (2003) 14023-14035. Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity Evidence URLhttps://www.uniprot.org/uniprotkb/P83719/entry
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