‹ ›
MYP_031238
← PREVIOUS NEXT → BACK
Basic Information
Ranacyclin-T
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C85H134N24O21S2
Standard
Sequence
GALRGCWTKSYPPKPCK
Physicochemical Analysis
1892.25 Da
9.70
3.74
3.50
0.2198
-0.88
0.26
-0.15
25.56
28.82
0.1176
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
718.99
-6.44
27.0
27.0
56.0
132.0
6.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0023251 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Ranacyclin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
P.nicotianae spores
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0024424 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli D21
30 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0037515 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
6-16
C-terminal amidation and one S-S bond. It differs from ranacyclin E (next entry) only at the N-terminus. Active against Gram- E. coli D21 (MIC 30 uM), Y. pseudotuberculosis YP III (MIC 5 uM), Ps. syringae pv tabaci (MIC 16 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 10 uM), M. luteus (MIC 8 uM), fungi C. albicansc ATCC 10231 (MIC 22 uM), C. tropicalis (MIC 14 uM), C. guiller-mondii (MIC 1 uM), P. nicotianae spores (MIC 16 uM). 20% hemolysis at 100 uM. Updated 5/2020
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus megaterium Bm11
3 μM
MIC
PaperRanacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity.
RECORD: Rec_0040365 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus lentus
10 μM
MIC
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
RECORD: Rec_0051131 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
6-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID14636071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14636071/
1 2 3 ... 9 NEXT LAST
Showing 5 records on this page · Page 1 of 9