Peptide Database

Peptide NameMedusin-PT

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length67 amino acids

Chemical FormulaC341H553N87O108S3

DescriptionStandard

        MAFLKKSLFLVFFLGFVSLSICEEEKRETDEKENEQEDDREERSEEKRLLGMIPVAITAISALSKLG
    

Molecular Weight7695.75 Da

Isoelectric Point (pI)4.69

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.74

Charge Density (pH 7.0) -0.0818

GRAVY Index-0.26

Hydrophobic Moment 0.47

Boman Index-0.05

Instability Index57.73

Aliphatic Index 94.63

Aromaticity 0.0746

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3186.37

LogP -26.42

H-bond Donors 111.0

H-bond Acceptors 106.0

Rotatable Bonds 273.0

Heavy Atoms 539.0

Ring Count 6.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067354 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyFrog skin active peptide (FSAP); Medusin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Anti-inflammatory Cytotoxic Hemolytic

TargetCandida albicans

RECORD: Rec_0108736 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyFrog skin active peptide (FSAP); Medusin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Anti-inflammatory Cytotoxic Hemolytic

TargetEnterococcus faecalis (Gram-positive)

RECORD: Rec_0287607 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyFrog skin active peptide (FSAP); Medusin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Anti-inflammatory Cytotoxic Hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0296472 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyFrog skin active peptide (FSAP); Medusin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Anti-inflammatory Cytotoxic Hemolytic

TargetS. epidermidis (Gram-positive)

RECORD: Rec_0386137 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa tarsius [Animal]

FamilyFrog skin active peptide (FSAP); Medusin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Anticancer Anti-inflammatory Cytotoxic Hemolytic

TargetEscherichia coli (Gram-negative)