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MYP_031131
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Basic Information
HB43
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C72H129N17O14
Standard
Sequence
FAKLLAKLAKKLL
Physicochemical Analysis
1456.90 Da
10.48
3.76
3.55
0.2889
0.89
0.71
0.18
-10.36
173.08
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
516.60
0.26
18.0
18.0
53.0
103.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294431 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
PaperPatent US 2011/0319336 A1 Evidence URLhttps://patents.google.com/patent/US20110319336A1/en PatentUS 2011/0319336 A1
RECORD: Rec_0297356 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
RECORD: Rec_0305902 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
H-1299
6 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0312912 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
9 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0355094 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK / Hecate / Shiva peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
HT-29
11.0 μM
IC50 / MTT-MTS assay
PaperPMID 35631675; HB43 synthetic peptide report PMID35631675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35631675/ PatentUS_06875744_B2
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