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MYP_031131
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Basic Information
HB43
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C72H129N17O14
Standard
Sequence
FAKLLAKLAKKLL
Physicochemical Analysis
1456.90 Da
10.48
3.76
3.55
0.2889
0.89
0.71
0.18
-10.36
173.08
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
516.60
0.26
18.0
18.0
53.0
103.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165543 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HB43-related peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
MDA-MB-231 (breast cancer)
20 μM
AlamarBlue assay
PaperThe Influence of Short Motifs on the Anticancer Activity of HB43 Peptide | https://pubmed.ncbi.nlm.nih.gov/35631675/ PMID35631675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35631675/
RECORD: Rec_0177108 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HB43-related peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
HT-29 (colon cancer)
11 ± 1 μM
IC50
PaperThe Influence of Short Motifs on the Anticancer Activity of HB43 Peptide | https://pubmed.ncbi.nlm.nih.gov/35631675/ PMID35631675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35631675/
RECORD: Rec_0191446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK / Hecate / Shiva peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
MDA-MB-231
20.0 μM
50% cell viability / MTT-MTS assay
PaperPMID 35631675; HB43 synthetic peptide report PMID35631675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35631675/ PatentUS_06875744_B2
RECORD: Rec_0254492 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
SW-480
9 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0265547 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
MIC against Pseudomonas aeruginosa PAO7
PMID24277028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24277028/
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