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MYP_031131
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Basic Information
HB43
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C72H129N17O14
Standard
Sequence
FAKLLAKLAKKLL
Physicochemical Analysis
1456.90 Da
10.48
3.76
3.55
0.2889
0.89
0.71
0.18
-10.36
173.08
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
516.60
0.26
18.0
18.0
53.0
103.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0070519 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HB43-related peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
SW-620 (colon cancer)
10 ± 1 μM
IC50
PaperThe Influence of Short Motifs on the Anticancer Activity of HB43 Peptide | https://pubmed.ncbi.nlm.nih.gov/35631675/ PMID35631675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35631675/
RECORD: Rec_0104577 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
12 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0110382 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0123614 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
4 μg/mL
MIC
PMID28453851 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28453851/
RECORD: Rec_0137901 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
BMKC
7 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
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