‹ ›
MYP_031050
← PREVIOUS NEXT → BACK
Basic Information
Brevinin-1E (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C128H209N31O27S2
Standard
Sequence
FLPLLAGLAANFLPKIFCKITRKC
Physicochemical Analysis
2678.35 Da
9.85
3.74
3.50
0.1557
0.95
0.78
0.29
12.30
126.25
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
918.32
-2.93
33.0
33.0
86.0
188.0
5.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0217748 VERIFIED: YES
Provenance & Taxonomy
Edible frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8163497/
RECORD: Rec_0229190 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 8.3%, T 62.5%, C 29.2% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0231306 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
2.33 μM
MIC
PaperMi-Yun Kwon et al. / Biochimica et Biophysica Acta 1387 (1998) 239-248. Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta Evidence URLhttps://www.uniprot.org/uniprotkb/P84839/entry
RECORD: Rec_0240310 VERIFIED: YES
Provenance & Taxonomy
Pelophylax ridibundus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
2.33 μM
MIC
PaperMi-Yun Kwon et al. / Biochimica et Biophysica Acta 1387 (1998) 239-248. Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta Evidence URLhttps://www.uniprot.org/uniprotkb/P86149/entry
RECORD: Rec_0249116 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic
Bacillus megaterium Bm11
0.4 μM
MIC
PMID8508915;8163497 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
FIRST PREV 1 ... 4 5 6 7 8 ... 10 NEXT LAST
Showing 5 records on this page · Page 6 of 10