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MYP_031050
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Basic Information
Brevinin-1E (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C128H209N31O27S2
Standard
Sequence
FLPLLAGLAANFLPKIFCKITRKC
Physicochemical Analysis
2678.35 Da
9.85
3.74
3.50
0.1557
0.95
0.78
0.29
12.30
126.25
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
918.32
-2.93
33.0
33.0
86.0
188.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0082808 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Mouse erythrocytes
1.1 μg/mL
Paperhttps://pubmed.ncbi.nlm.nih.gov/9748603/ PMID9748603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9748603/
RECORD: Rec_0084157 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli D21 (LC 1.8 uM), Bacillus megaterium BmII, Staphylococcus aureus Cowan 1 (LC 0.4-0.6 uM), Pseudomonas aeruginosa ATCC 15692 (LC 30.6 uM), Candida albicans
PaperAntimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides.
RECORD: Rec_0084227 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
18-24
Bio-Activity Profile
Antimicrobial Antifungal Insulin releasing
PaperL. Marenah et al. / Journal of Endocrinology 188 (2006) 1-9. Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity Evidence URLhttps://www.uniprot.org/uniprotkb/P84839/entry
RECORD: Rec_0101131 VERIFIED: YES
Provenance & Taxonomy
Rana ridibunda [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
shows hemolytic activity
Hemolysis
PaperBrevinin-1E Evidence URLhttps://www.uniprot.org/uniprotkb/P86149/entry
RECORD: Rec_0103905 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
10 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/15232222/ PMID15232222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15232222/
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