Peptide Database

Peptide NameCliotide T12

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC131H213N35O40S6

DescriptionStandard

        GIPCGESCVFIPCITGAIGCSCKSKVCYRD
    

Molecular Weight3110.69 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.70

Net Charge (pH 7.4) 0.41

Charge Density (pH 7.0) 0.0235

GRAVY Index0.58

Hydrophobic Moment 0.30

Boman Index0.20

Instability Index8.89

Aliphatic Index 74.67

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1179.33

LogP -13.50

H-bond Donors 47.0

H-bond Acceptors 47.0

Rotatable Bonds 98.0

Heavy Atoms 212.0

Ring Count 4.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034919 VERIFIED: NO

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

FamilyCyclotide

Structure & Mods

Configbackbone-cyclized peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-20; 8-22; 13-27

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0202365 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

FamilyCyclotide

Tax ID43366

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Cytotoxic

TargetHeLa cells

RECORD: Rec_0218179 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

RECORD: Rec_0347344 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

FamilyCyclotide

Tax ID43366

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antibacterial Cytotoxic Anti-Gram-negative

TargetEscherichia coli