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MYP_030774
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Basic Information
Ovispirin
Anticancer
Anticancer ▸ Anti-proliferative
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C105H188N34O21
Standard
Sequence
KNLRRIIRKIIHIIKKYG
Physicochemical Analysis
2262.83 Da
11.75
6.84
6.58
0.3801
-0.37
1.04
-0.26
69.08
151.67
0.0556
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
939.80
-4.31
35.0
29.0
83.0
160.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006832 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei 427 (blood stage form)
50 μM
Percent inhibition; MTT assay
PaperKilling of African trypanosomes by antimicrobial peptides PMID12825184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12825184/
RECORD: Rec_0015595 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
M. haemolytica serovar
3.8 μg/mL
MIC
PaperCongeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.
RECORD: Rec_0053946 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPDB 1HU5 structural record; NMR; chain A; residues 1-18
RECORD: Rec_0066732 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
40 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11932493/ PMID11932493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11932493/
RECORD: Rec_0079481 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal]
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer Anti-proliferative
PaperPatent US 7071293 B1 Evidence URLhttps://patents.google.com/patent/US7071293B1/en PatentUS 7071293 B1
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