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MYP_030765
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Basic Information
RJ5
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C99H191N33O22
Standard
Sequence
AKKAAKKAKKAAKKAKKAAKK
Physicochemical Analysis
2195.78 Da
11.04
11.78
11.58
0.5611
-1.46
0.71
-0.59
9.52
42.86
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
957.56
-9.18
34.0
34.0
89.0
154.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006904 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
herpes simplex virus 1 (HSV-1) | MRC-5 cells
41 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 Nov;64(2):119-26. | DOI:10.1016/j.antiviral.2004.08.003 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0014481 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
herpes simplex virus 1(HSV-1):inhibition of HSV-1 infection in MRC-5 cells
41 μM
IC50
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0156761 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
human fibroblasts(MRC-5 cells)
468 μM
CC50
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0170095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
herpes simplex virus 2 (HSV-2) | MRC-5 cells
14.3 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 Nov;64(2):119-26. | DOI:10.1016/j.antiviral.2004.08.003 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0178873 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
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