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MYP_030739
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Basic Information
Cupiennin 1b
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
35 amino acids
C175H287N47O45S
Standard
Sequence
GFGSLFKFLAKKVAKTVAKQAAKQGAKYIANKQME
Physicochemical Analysis
3801.50 Da
10.30
6.76
6.54
0.1931
-0.27
0.69
-0.01
27.60
70.00
0.1143
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1531.23
-13.26
52.0
53.0
136.0
268.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0146929 VERIFIED: YES
Provenance & Taxonomy
American wandering [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID11792701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11792701/
RECORD: Rec_0147158 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Cupiennin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 29213
PMID11792701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11792701/
RECORD: Rec_0162427 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Cationic peptide 04 (cupiennin); 01 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic Insecticidal
Enterococcus faecalis
PMID11792701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11792701/
RECORD: Rec_0211066 VERIFIED: YES
Provenance & Taxonomy
Cupiennius salei [Animal]
Cupiennin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal
PaperJ Biol Chem. 2002 Mar 29;277(13):11208-16. Epub 2002 Jan 15. | http://www.ncbi.nlm.nih.gov/pubmed/11792701 PMID11792701 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11792701/
RECORD: Rec_0213314 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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