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MYP_030723
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Basic Information
HIV-TAT48-57
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
10 amino acids
C55H109N31O12
Standard
Sequence
GRKKRRQRRR
Physicochemical Analysis
1396.65 Da
12.00
7.76
7.55
0.7758
-3.87
0.51
-1.85
232.70
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
791.75
-10.50
32.0
20.0
54.0
98.0
0.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250994 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cell-penetrating peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
HeLa
50 μM
Concentration response
PMID15467750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15467750/
RECORD: Rec_0253302 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cell-penetrating peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
HeLa
10 μM
Concentration response
PMID15467750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15467750/
RECORD: Rec_0254588 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: ester; Conjugated small molecule: Rose bengal (xanthene dye)
Bio-Activity Profile
-
PaperSynthesis, Characterization, and Cellular Uptake of DNA-Binding Rose Bengal Peptidoconjugates. Organic Letters. 2005 Evidence URLhttps://doi.org/10.1021/ol047762+
RECORD: Rec_0288555 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Fluorescein/FITC labeling
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22413929 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22413929/
RECORD: Rec_0312916 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Addition of cysteine and BSH
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24452095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24452095/
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