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MYP_030723
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Basic Information
HIV-TAT48-57
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
10 amino acids
C55H109N31O12
Standard
Sequence
GRKKRRQRRR
Physicochemical Analysis
1396.65 Da
12.00
7.76
7.55
0.7758
-3.87
0.51
-1.85
232.70
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
791.75
-10.50
32.0
20.0
54.0
98.0
0.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0199931 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23871961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871961/
RECORD: Rec_0216748 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled with Cys-acetamidomethyl
Labelled with fluorescein maleimide
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0226981 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | MAGI cells
67.3 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperKeogan S, Passic S, Krebs FC. | Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat. | Int J Pept. 2012;2012:349427. | DOI:10.1155/2012/349427 | PMID:22319541 PMID22319541 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
RECORD: Rec_0240158 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Conjugated with Gd³⁺-DOTA via CAT recognition site
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23281285 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23281285/
RECORD: Rec_0247592 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID15467750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15467750/
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