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MYP_030723
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Basic Information
HIV-TAT48-57
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
10 amino acids
C55H109N31O12
Standard
Sequence
GRKKRRQRRR
Physicochemical Analysis
1396.65 Da
12.00
7.76
7.55
0.7758
-3.87
0.51
-1.85
232.70
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
791.75
-10.50
32.0
20.0
54.0
98.0
0.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142842 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Fluorescein/FITC labeling
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23281285 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23281285/
RECORD: Rec_0161135 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Membrane-active peptide
PaperFerrer - Miralles N., Vazquez E., Villaverde A.. Membrane-active peptides fro non-viral gene therapy: making the safest easier. Trends Biotechnol., 2008, 26, 5, 267-275.
RECORD: Rec_0174731 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
P4-R5 MAG
50 μM
IC50
PaperInfection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat. PMID22319541 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
RECORD: Rec_0177029 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Porphine derivative
Bio-Activity Profile
Anticancer
PaperPeptide-Mediated Cell Transport of Water Soluble Porphyrin Conjugates. Journal of Medicinal Chemistry. 2006 Evidence URLhttps://doi.org/10.1021/jm050893b
RECORD: Rec_0186059 VERIFIED: NO
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cys-acetamidomethyl labeling
Fluorophore labeling
N-term detail: Labelled with Cys-acetamidomethyl; C-term detail: Labelled with fluorescein maleimide
Bio-Activity Profile
Cell-penetrating peptide
HeLa
Fluorescence-based uptake assay
Evidence URLhttps://patents.google.com/patent/US20100216716/en PatentUS20100216716
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